Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease

Autosomal-dominant (AD) polycystic kidney disease (PKD) is a leading cause of renal failure in the United States, and currently lacks available treatment options to slow disease progression. Mutations in the gene coding for polycystin-1 (PC1) underlie the majority of cases but the function of PC1 ha...

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Bibliographic Details
Main Authors: Olsan, Erin E., Mukherjee, Sambuddho, Wulkersdorfer, Beatrix, Shillingford, Jonathan M., Giovannone, Adrian J., Todorov, Gueorgui, Song, Xuewen, Pei, York, Weimbs, Thomas
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207695/
https://ncbi.nlm.nih.gov/pubmed/22025716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111966108
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