Polycystin-1 C-terminal tail associates with β-catenin and inhibits canonical Wnt signaling

Polycystin-1 (PC1), the product of the PKD1 gene mutated in the majority of autosomal dominant polycystic kidney disease (ADPKD) cases, undergoes a cleavage resulting in the intracellular release of its C-terminal tail (CTT). Here, we demonstrate that the PC1 CTT co-localizes with and binds to β-cat...

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Detalhes bibliográficos
Main Authors: Lal, Mark, Song, Xuewen, Pluznick, Jennifer L., Di Giovanni, Valeria, Merrick, David M., Rosenblum, Norman D., Chauvet, Veronique, Gottardi, Cara J., Pei, York, Caplan, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722884/
https://ncbi.nlm.nih.gov/pubmed/18632682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn208
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