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Polycystin-1 C-terminal tail associates with β-catenin and inhibits canonical Wnt signaling
Polycystin-1 (PC1), the product of the PKD1 gene mutated in the majority of autosomal dominant polycystic kidney disease (ADPKD) cases, undergoes a cleavage resulting in the intracellular release of its C-terminal tail (CTT). Here, we demonstrate that the PC1 CTT co-localizes with and binds to β-cat...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2722884/ https://ncbi.nlm.nih.gov/pubmed/18632682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn208 |
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