The carboxy‐terminus of the human ARPKD protein fibrocystin can control STAT3 signalling by regulating SRC‐activation

Autosomal recessive polycystic kidney disease (ARPKD) is mainly caused by variants in the PKHD1 gene, encoding fibrocystin (FC), a large transmembrane protein of incompletely understood cellular function. Here, we show that a C‐terminal fragment of human FC can suppress a signalling module of the ki...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Dafinger, Claudia, Mandel, Amrei M., Braun, Alina, Göbel, Heike, Burgmaier, Kathrin, Massella, Laura, Mastrangelo, Antonio, Dötsch, Jörg, Benzing, Thomas, Weimbs, Thomas, Schermer, Bernhard, Liebau, Max C.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Short Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754027/
https://ncbi.nlm.nih.gov/pubmed/33112055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.16014
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