Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice

It has been hypothesized that α-synuclein (αS) misfolding may begin in peripheral nerves and spread to the central nervous system (CNS), leading to Parkinson disease and related disorders. Although recent data suggest that αS pathology can spread within the mouse brain, there is no direct evidence f...

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Autores principales: Sacino, Amanda N., Brooks, Mieu, Thomas, Michael A., McKinney, Alex B., Lee, Sooyeon, Regenhardt, Robert W., McGarvey, Nicholas H., Ayers, Jacob I., Notterpek, Lucia, Borchelt, David R., Golde, Todd E., Giasson, Benoit I.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2014
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115570/
https://ncbi.nlm.nih.gov/pubmed/25002524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321785111
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