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CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70

Exposure of cells to various stresses often leads to the induction of a group of proteins called heat shock proteins (HSPs, molecular chaperones)(1,2). Hsp70 is one of the most highly inducible molecular chaperones, but its expression must be maintained at low levels under physiological conditions t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Qian, Shu-Bing, McDonough, Holly, Boellmann, Frank, Cyr, Douglas M., Patterson, Cam
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112096/
https://ncbi.nlm.nih.gov/pubmed/16554822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature04600
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