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The Ubiquitin Ligase CHIP Prevents SirT6 Degradation through Noncanonical Ubiquitination
The ubiquitin ligase CHIP (carboxyl terminus of Hsp70-interacting protein) regulates protein quality control, and CHIP deletion accelerates aging and reduces the life span in mice. Here, we reveal a mechanism for CHIP's influence on longevity by demonstrating that CHIP stabilizes the sirtuin fa...
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| Main Authors: | , , , |
|---|---|
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
American Society for Microbiology
2013
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3838192/ https://ncbi.nlm.nih.gov/pubmed/24043303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00480-13 |
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