Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2 hydroxyglutarate (2HG) production. Mutational and epigenetic profiling of a large AML patient cohort revealed that IDH1/2-mutant AMLs display global DNA hypermethylation and a specific hypermethylation si...

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Hoofdauteurs: Figueroa, Maria E., Wahab, Omar Abdel, Lu, Chao, Ward, Patrick S., Patel, Jay, Shih, Alan, Li, Yushan, Bhagwat, Neha, Vasanthakumar, Aparna, Fernandez, Hugo F., Tallman, Martin S., Sun, Zhuoxin, Wolniak, Kristy, Peeters, Justine K., Liu, Wei, Choe, Sung E, Fantin, Valeria R., Paietta, Elisabeth, Löwenberg, Bob, Licht, Jonathan D., Godley, Lucy A, Delwel, Ruud, Valk, Peter J.M., Thompson, Craig B., Levine, Ross L., Melnick, Ari
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4105845/
https://ncbi.nlm.nih.gov/pubmed/21130701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.11.015
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