Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR

The cause of insulin insufficiency remains unknown in many diabetic cases. Up to 50% adult patients with cystic fibrosis (CF), a disease caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR), develop CF-related diabetes (CFRD) with most patients exhibiting insuli...

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Autors principals: Guo, Jing Hui, Chen, Hui, Ruan, Ye Chun, Zhang, Xue Lian, Zhang, Xiao Hu, Fok, Kin Lam, Tsang, Lai Ling, Yu, Mei Kuen, Huang, Wen Qing, Sun, Xiao, Chung, Yiu Wa, Jiang, Xiaohua, Sohma, Yoshiro, Chan, Hsiao Chang
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104438/
https://ncbi.nlm.nih.gov/pubmed/25025956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5420
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