CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo development

Although HCO(3)(−) is known to be required for early embryo development, its exact role remains elusive. Here we report that HCO(3)(−) acts as an environmental cue in regulating miR-125b expression through CFTR-mediated influx during preimplantation embryo development. The results show that the effe...

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Detalhes bibliográficos
Main Authors: Lu, Yong Chao, Chen, Hui, Fok, Kin Lam, Tsang, Lai Ling, Yu, Mei Kuen, Zhang, Xiao Hu, Chen, Jing, Jiang, Xiaohua, Chung, Yiu Wa, Ma, Alvin Chun Hang, Leung, Anskar Yu Hung, Huang, He Feng, Chan, Hsiao Chang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463266/
https://ncbi.nlm.nih.gov/pubmed/22664907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.88
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