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Evidence of abundant purifying selection in humans for recently-acquired regulatory functions
While only 5% of the human genome is conserved across mammals, a substantially larger portion is biochemically active, raising the question of whether the additional elements evolve neutrally or confer a lineage-specific fitness advantage. To address this question, we integrate human variation infor...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4104271/ https://ncbi.nlm.nih.gov/pubmed/22956687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1225057 |
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