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Evidence of reduced recombination rate in human regulatory domains

BACKGROUND: Recombination rate is non-uniformly distributed across the human genome. The variation of recombination rate at both fine and large scales cannot be fully explained by DNA sequences alone. Epigenetic factors, particularly DNA methylation, have recently been proposed to influence the vari...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Genome Biol
Main Authors: Liu, Yaping, Sarkar, Abhishek, Kheradpour, Pouya, Ernst, Jason, Kellis, Manolis
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651596/
https://ncbi.nlm.nih.gov/pubmed/29058599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1308-x
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