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Evidence of reduced recombination rate in human regulatory domains

BACKGROUND: Recombination rate is non-uniformly distributed across the human genome. The variation of recombination rate at both fine and large scales cannot be fully explained by DNA sequences alone. Epigenetic factors, particularly DNA methylation, have recently been proposed to influence the vari...

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Bibliografische gegevens
Gepubliceerd in:Genome Biol
Hoofdauteurs: Liu, Yaping, Sarkar, Abhishek, Kheradpour, Pouya, Ernst, Jason, Kellis, Manolis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651596/
https://ncbi.nlm.nih.gov/pubmed/29058599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1308-x
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