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Evidence of reduced recombination rate in human regulatory domains

BACKGROUND: Recombination rate is non-uniformly distributed across the human genome. The variation of recombination rate at both fine and large scales cannot be fully explained by DNA sequences alone. Epigenetic factors, particularly DNA methylation, have recently been proposed to influence the vari...

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Publicado en:Genome Biol
Main Authors: Liu, Yaping, Sarkar, Abhishek, Kheradpour, Pouya, Ernst, Jason, Kellis, Manolis
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651596/
https://ncbi.nlm.nih.gov/pubmed/29058599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1308-x
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