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Evidence of abundant purifying selection in humans for recently-acquired regulatory functions

While only 5% of the human genome is conserved across mammals, a substantially larger portion is biochemically active, raising the question of whether the additional elements evolve neutrally or confer a lineage-specific fitness advantage. To address this question, we integrate human variation infor...

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Detalhes bibliográficos
Main Authors: Ward, Lucas D., Kellis, Manolis
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104271/
https://ncbi.nlm.nih.gov/pubmed/22956687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1225057
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