Negative regulation of DAB2IP by Akt and SCF(Fbw7) pathways

Deletion of ovarian carcinoma 2/disabled homolog 2 (DOC-2/DAB2) interacting protein (DAB2IP), is a tumor suppressor that serves as a scaffold protein involved in coordinately regulating cell proliferation, survival and apoptotic pathways. DAB2IP is epigenetically down-regulated in a variety of tumor...

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Bibliographic Details
Main Authors: Dai, Xiangping, North, Brian J., Inuzuka, Hiroyuki
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2014
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102811/
https://ncbi.nlm.nih.gov/pubmed/24912918
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