SCF(Fbw7) Modulates the NFκB Signaling Pathway by Targeting NFκB2 for Ubiquitination and Destruction

The NFκB/Rel family of proteins play critical roles in a variety of cellular processes. Thus, their physiological activation is tightly controlled. Recently, the NFκB2/p100 precursor has been characterized as the fourth IκB type of suppressor for NFκB. However, the molecular mechanism(s) underlying...

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Detalhes bibliográficos
Main Authors: Fukushima, Hidefumi, Matsumoto, Akinobu, Inuzuka, Hiroyuki, Zhai, Bo, Lau, Alan W., Wan, Lixin, Gao, Daming, Shaik, Shavali, Yuan, Min, Gygi, Steven P., Jimi, Eijiro, Asara, John M., Nakayama, Keiko, Nakayama, Keiichi I., Wei, Wenyi
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375724/
https://ncbi.nlm.nih.gov/pubmed/22708077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.04.002
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