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Environmental contaminants perturb fragile protein assemblies and inhibit normal protein function

The molecular mechanisms whereby small molecules that contaminate our environment cause physiological effects are largely unknown, in terms of both targets and mechanisms. The essential human enzyme porphobilinogen synthase (HsPBGS, a.k.a. 5-aminolevulinate dehydratase, ALAD) functions in heme biosy...

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Autori principali: Lawrence, Sarah H., Selwood, Trevor, Jaffe, Eileen K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102012/
https://ncbi.nlm.nih.gov/pubmed/25045409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/2212796811307020011
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