The Anti-Diabetic Drug Metformin Reduces BACE1 Protein Level by Interfering with the MID1 Complex

Alzheimer’s disease (AD), the most common form of dementia in the elderly, is characterized by two neuropathological hallmarks: senile plaques, which are composed of Aβ peptides, and neurofibrillary tangles, which are composed of hyperphosphorylated TAU protein. Diabetic patients with dysregulated i...

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Bibliographic Details
Main Authors: Hettich, Moritz M., Matthes, Frank, Ryan, Devon P., Griesche, Nadine, Schröder, Susanne, Dorn, Stephanie, Krauß, Sybille, Ehninger, Dan
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4099345/
https://ncbi.nlm.nih.gov/pubmed/25025689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102420
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