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The Anti-Diabetic Drug Metformin Reduces BACE1 Protein Level by Interfering with the MID1 Complex

Alzheimer’s disease (AD), the most common form of dementia in the elderly, is characterized by two neuropathological hallmarks: senile plaques, which are composed of Aβ peptides, and neurofibrillary tangles, which are composed of hyperphosphorylated TAU protein. Diabetic patients with dysregulated i...

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Detalhes bibliográficos
Main Authors: Hettich, Moritz M., Matthes, Frank, Ryan, Devon P., Griesche, Nadine, Schröder, Susanne, Dorn, Stephanie, Krauß, Sybille, Ehninger, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4099345/
https://ncbi.nlm.nih.gov/pubmed/25025689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102420
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