PGC-1α rescues Huntington’s disease proteotoxicity by preventing oxidative stress and promoting TFEB function

Huntington’s disease (HD) is caused by CAG / polyglutamine repeat expansions in the huntingtin (htt) gene, yielding proteins that misfold and resist degradation. HD belongs to a large class of neurodegenerative proteinopathies including Alzheimer’s disease, Parkinson’s disease, and tauopathies. Prev...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Tsunemi, Taiji, Ashe, Travis D., Morrison, Bradley E., Soriano, Kathryn R., Au, Jonathan, Vázquez Roque, Ruben A., Lazarowski, Eduardo R., Damian, Vincent A., Masliah, Eliezer, La Spada, Albert R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096245/
https://ncbi.nlm.nih.gov/pubmed/22786682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003799
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados