PGC-1α rescues Huntington’s disease proteotoxicity by preventing oxidative stress and promoting TFEB function

Huntington’s disease (HD) is caused by CAG / polyglutamine repeat expansions in the huntingtin (htt) gene, yielding proteins that misfold and resist degradation. HD belongs to a large class of neurodegenerative proteinopathies including Alzheimer’s disease, Parkinson’s disease, and tauopathies. Prev...

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Autori principali: Tsunemi, Taiji, Ashe, Travis D., Morrison, Bradley E., Soriano, Kathryn R., Au, Jonathan, Vázquez Roque, Ruben A., Lazarowski, Eduardo R., Damian, Vincent A., Masliah, Eliezer, La Spada, Albert R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096245/
https://ncbi.nlm.nih.gov/pubmed/22786682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003799
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