The deadly connection between endoplasmic reticulum, Ca(2+), protein synthesis, and the endoplasmic reticulum stress response in malignant glioma cells

BACKGROUND: The endoplasmic reticulum (ER) is involved in Ca(2+) signaling and protein processing. Accumulation of unfolded proteins following ER Ca(2+) depletion triggers the ER stress response (ERSR), which facilitates protein folding and removal of damaged proteins and can induce cell death. Unfo...

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Detalles Bibliográficos
Main Authors: Johnson, Guyla G., White, Misti C., Wu, Jian-He, Vallejo, Matthew, Grimaldi, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
Assuntos:
Basic and Translational Investigations
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096176/
https://ncbi.nlm.nih.gov/pubmed/24569545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou012
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