Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways

BACKGROUND: Glioblastoma multiforme (GBM), the most aggressive malignant primary brain tumor of the central nervous system, is characterized by a relentless disease recurrence despite continued advancement in surgery, radiotherapy, and chemotherapy. Resistance to temozolomide (TMZ), a standard chemo...

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Detalhes bibliográficos
Main Authors: Sun, Stella, Lee, Derek, Ho, Amy S.W., Pu, Jenny K.S., Zhang, X.Q., Lee, Nikki P., Day, Philip J.R., Lui, W.M., Fung, C.F., Leung, Gilberto K.K.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635523/
https://ncbi.nlm.nih.gov/pubmed/23444257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not005
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