Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells

BACKGROUNDS: Piperlongumine, a natural plant product, kills multiple cancer types with little effect on normal cells. Piperlongumine raises intracellular levels of reactive oxygen species (ROS), a phenomenon that may underlie the cancer-cell killing. Although these findings suggest that piperlongumi...

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Detalhes bibliográficos
Main Authors: Kim, Tae Hyong, Song, Jieun, Kim, Sung-Hak, Parikh, Arav Krishnavadan, Mo, Xiaokui, Palanichamy, Kamalakannan, Kaur, Balveen, Yu, Jianhua, Yoon, Sung Ok, Nakano, Ichiro, Kwon, Chang-Hyuk
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165421/
https://ncbi.nlm.nih.gov/pubmed/24879047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou088
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