Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV

Broadly neutralizing monoclonal antibodies (bnMAbs) that target the high-mannose patch centered around the glycan at position 332 on HIV Env are promising vaccine leads and therapeutic candidates as they effectively protect against mucosal SHIV challenge and strongly suppress SHIV viraemia in establ...

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Bibliographic Details
Main Authors: Sok, Devin, Doores, Katie J., Briney, Bryan, Le, Khoa M., Saye-Francisco, Karen F., Ramos, Alejandra, Kulp, Daniel W., Julien, Jean-Philippe, Menis, Sergey, Wickramasinghe, Lalinda, Seaman, Michael S., Schief, William R., Wilson, Ian A., Poignard, Pascal, Burton, Dennis R.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4095976/
https://ncbi.nlm.nih.gov/pubmed/24828077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3008104
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