Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies

The envelope spike of HIV-1 employs a ‘glycan shield’ to protect itself from antibody-mediated neutralization. Paradoxically, however, potent broadly neutralizing antibodies (bnAbs) have been isolated which target this shield. The unusually high glycan density on the gp120 subunit limits processing...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Pritchard, Laura K., Spencer, Daniel I. R., Royle, Louise, Bonomelli, Camille, Seabright, Gemma E., Behrens, Anna-Janina, Kulp, Dan, Menis, Sergey, Krumm, Stefanie A., Dunlop, D. Cameron, Crispin, Daniel J., Bowden, Thomas A., Scanlan, Christopher N., Ward, Andrew B., Schief, William R., Doores, Katie J., Crispin, Max
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500839/
https://ncbi.nlm.nih.gov/pubmed/26105115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8479
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados