Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies

The envelope spike of HIV-1 employs a ‘glycan shield’ to protect itself from antibody-mediated neutralization. Paradoxically, however, potent broadly neutralizing antibodies (bnAbs) have been isolated which target this shield. The unusually high glycan density on the gp120 subunit limits processing...

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Vydáno v:Nat Commun
Hlavní autoři: Pritchard, Laura K., Spencer, Daniel I. R., Royle, Louise, Bonomelli, Camille, Seabright, Gemma E., Behrens, Anna-Janina, Kulp, Dan, Menis, Sergey, Krumm, Stefanie A., Dunlop, D. Cameron, Crispin, Daniel J., Bowden, Thomas A., Scanlan, Christopher N., Ward, Andrew B., Schief, William R., Doores, Katie J., Crispin, Max
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500839/
https://ncbi.nlm.nih.gov/pubmed/26105115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8479
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