Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch

The high-mannose patch on HIV Env is a preferred target for broadly neutralizing antibodies (bnAbs), but to date, no vaccination regimen has elicited bnAbs against this region. Here, we present the development of a bnAb lineage targeting the high-mannose patch in an HIV-1 subtype-C-infected donor fr...

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Vydáno v:Immunity
Hlavní autoři: MacLeod, Daniel T., Choi, Nancy M., Briney, Bryan, Garces, Fernando, Ver, Lorena S., Landais, Elise, Murrell, Ben, Wrin, Terri, Kilembe, William, Liang, Chi-Hui, Ramos, Alejandra, Bian, Chaoran B., Wickramasinghe, Lalinda, Kong, Leopold, Eren, Kemal, Wu, Chung-Yi, Wong, Chi-Huey, Kosakovsky Pond, Sergei L., Wilson, Ian A., Burton, Dennis R., Poignard, Pascal
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003182/
https://ncbi.nlm.nih.gov/pubmed/27192579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.04.016
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