HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage

Understanding how broadly neutralizing antibodies (bnAbs) to HIV envelope (Env) develop during natural infection can help guide the rational design of an HIV vaccine. Here, we described a bnAb lineage targeting the Env V2 apex and the Ab-Env co-evolution that led to development of neutralization bre...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Landais, Elise, Murrell, Ben, Briney, Bryan, Murrell, Sasha, Rantalainen, Kimmo, Berndsen, Zachary T., Ramos, Alejandra, Wickramasinghe, Lalinda, Smith, Melissa Laird, Eren, Kemal, de Val, Natalia, Wu, Mengyu, Cappelletti, Audrey, Umotoy, Jeffrey, Lie, Yolanda, Wrin, Terri, Algate, Paul, Chan-Hui, Po-Ying, Karita, Etienne, Ward, Andrew B., Wilson, Ian A., Burton, Dennis R., Smith, Davey, Kosakovsky Pond, Sergei L., Poignard, Pascal
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736302/
https://ncbi.nlm.nih.gov/pubmed/29166592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.11.002
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