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Model based engineering of Pichia pastoris central metabolism enhances recombinant protein production
The production of recombinant proteins is frequently enhanced at the levels of transcription, codon usage, protein folding and secretion. Overproduction of heterologous proteins, however, also directly affects the primary metabolism of the producing cells. By incorporation of the production of a het...
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| 主要な著者: | , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Academic Press
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4094982/ https://ncbi.nlm.nih.gov/pubmed/24853352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymben.2014.05.011 |
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