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Versatile modeling and optimization of fed batch processes for the production of secreted heterologous proteins with Pichia pastoris

BACKGROUND: Secretion of heterologous proteins depends both on biomass concentration and on the specific product secretion rate, which in turn is not constant at varying specific growth rates. As fed batch processes usually do not maintain a steady state throughout the feed phase, it is not trivial...

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書誌詳細
主要な著者: Maurer, Michael, Kühleitner, Manfred, Gasser, Brigitte, Mattanovich, Diethard
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1712348/
https://ncbi.nlm.nih.gov/pubmed/17156474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2859-5-37
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