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Versatile modeling and optimization of fed batch processes for the production of secreted heterologous proteins with Pichia pastoris

BACKGROUND: Secretion of heterologous proteins depends both on biomass concentration and on the specific product secretion rate, which in turn is not constant at varying specific growth rates. As fed batch processes usually do not maintain a steady state throughout the feed phase, it is not trivial...

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Autores principales: Maurer, Michael, Kühleitner, Manfred, Gasser, Brigitte, Mattanovich, Diethard
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1712348/
https://ncbi.nlm.nih.gov/pubmed/17156474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2859-5-37
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