Versatile modeling and optimization of fed batch processes for the production of secreted heterologous proteins with Pichia pastoris

BACKGROUND: Secretion of heterologous proteins depends both on biomass concentration and on the specific product secretion rate, which in turn is not constant at varying specific growth rates. As fed batch processes usually do not maintain a steady state throughout the feed phase, it is not trivial...

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Hlavní autoři: Maurer, Michael, Kühleitner, Manfred, Gasser, Brigitte, Mattanovich, Diethard
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2006
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1712348/
https://ncbi.nlm.nih.gov/pubmed/17156474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2859-5-37
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