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Increasing pentose phosphate pathway flux enhances recombinant protein production in Pichia pastoris
Production of heterologous proteins in Pichia pastoris (syn. Komagataella sp.) has been shown to exert a metabolic burden on the host metabolism. This burden is associated with metabolite drain, which redirects nucleotides and amino acids from primary metabolism. On the other hand, recombinant prote...
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| Publicado no: | Appl Microbiol Biotechnol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Berlin Heidelberg
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4909809/ https://ncbi.nlm.nih.gov/pubmed/27020289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-016-7363-5 |
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