Model based engineering of Pichia pastoris central metabolism enhances recombinant protein production

The production of recombinant proteins is frequently enhanced at the levels of transcription, codon usage, protein folding and secretion. Overproduction of heterologous proteins, however, also directly affects the primary metabolism of the producing cells. By incorporation of the production of a het...

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Detalhes bibliográficos
Main Authors: Nocon, Justyna, Steiger, Matthias G., Pfeffer, Martin, Sohn, Seung Bum, Kim, Tae Yong, Maurer, Michael, Rußmayer, Hannes, Pflügl, Stefan, Ask, Magnus, Haberhauer-Troyer, Christina, Ortmayr, Karin, Hann, Stephan, Koellensperger, Gunda, Gasser, Brigitte, Lee, Sang Yup, Mattanovich, Diethard
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094982/
https://ncbi.nlm.nih.gov/pubmed/24853352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymben.2014.05.011
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