Model based engineering of Pichia pastoris central metabolism enhances recombinant protein production

The production of recombinant proteins is frequently enhanced at the levels of transcription, codon usage, protein folding and secretion. Overproduction of heterologous proteins, however, also directly affects the primary metabolism of the producing cells. By incorporation of the production of a het...

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Detaylı Bibliyografya
Asıl Yazarlar: Nocon, Justyna, Steiger, Matthias G., Pfeffer, Martin, Sohn, Seung Bum, Kim, Tae Yong, Maurer, Michael, Rußmayer, Hannes, Pflügl, Stefan, Ask, Magnus, Haberhauer-Troyer, Christina, Ortmayr, Karin, Hann, Stephan, Koellensperger, Gunda, Gasser, Brigitte, Lee, Sang Yup, Mattanovich, Diethard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Academic Press 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094982/
https://ncbi.nlm.nih.gov/pubmed/24853352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymben.2014.05.011
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