Model based engineering of Pichia pastoris central metabolism enhances recombinant protein production

The production of recombinant proteins is frequently enhanced at the levels of transcription, codon usage, protein folding and secretion. Overproduction of heterologous proteins, however, also directly affects the primary metabolism of the producing cells. By incorporation of the production of a het...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Nocon, Justyna, Steiger, Matthias G., Pfeffer, Martin, Sohn, Seung Bum, Kim, Tae Yong, Maurer, Michael, Rußmayer, Hannes, Pflügl, Stefan, Ask, Magnus, Haberhauer-Troyer, Christina, Ortmayr, Karin, Hann, Stephan, Koellensperger, Gunda, Gasser, Brigitte, Lee, Sang Yup, Mattanovich, Diethard
التنسيق: Artigo
اللغة:Inglês
منشور في: Academic Press 2014
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094982/
https://ncbi.nlm.nih.gov/pubmed/24853352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymben.2014.05.011
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