Mitochondrial NLRP3 Protein Induces Reactive Oxygen Species to Promote Smad Protein Signaling and Fibrosis Independent from the Inflammasome

Nucleotide-binding domain and leucine-rich repeat containing PYD-3 (NLRP3) is a pattern recognition receptor that is implicated in the pathogenesis of inflammation and chronic diseases. Although much is known regarding the NLRP3 inflammasome that regulates proinflammatory cytokine production in inna...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bracey, Nathan A., Gershkovich, Benjamin, Chun, Justin, Vilaysane, Akosua, Meijndert, H. Christopher, Wright, James R., Fedak, Paul W., Beck, Paul L., Muruve, Daniel A., Duff, Henry J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2014
Pynciau:
Immunology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094069/
https://ncbi.nlm.nih.gov/pubmed/24841199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.550624
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