Mitochondrial NLRP3 Protein Induces Reactive Oxygen Species to Promote Smad Protein Signaling and Fibrosis Independent from the Inflammasome

Nucleotide-binding domain and leucine-rich repeat containing PYD-3 (NLRP3) is a pattern recognition receptor that is implicated in the pathogenesis of inflammation and chronic diseases. Although much is known regarding the NLRP3 inflammasome that regulates proinflammatory cytokine production in inna...

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Main Authors: Bracey, Nathan A., Gershkovich, Benjamin, Chun, Justin, Vilaysane, Akosua, Meijndert, H. Christopher, Wright, James R., Fedak, Paul W., Beck, Paul L., Muruve, Daniel A., Duff, Henry J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094069/
https://ncbi.nlm.nih.gov/pubmed/24841199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.550624
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