Population pharmacokinetics of nefopam in elderly, with or without renal impairment, and its link to treatment response

AIMS: Nefopam is a nonmorphinic central analgesic, for which no recommendation exists concerning adaptation of regimen in aged patients with or without renal impairment. The objective was to describe the pharmacology of nefopam in aged patients to obtain guidelines for practical use. METHODS: Elderl...

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Detalhes bibliográficos
Main Authors: Djerada, Zoubir, Fournet-Fayard, Aurélie, Gozalo, Claire, Lelarge, Chantal, Lamiable, Denis, Millart, Hervé, Malinovsky, Jean-Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2014
Assuntos:
Pharmacokinetic Dynamic Relationships
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4093928/
https://ncbi.nlm.nih.gov/pubmed/24252055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12291
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