Safety, tolerability, pharmacokinetics and pharmacodynamics of ascending single and multiple doses of lecozotan in healthy young and elderly subjects

AIMS: To determine the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of oral immediate release (IR) lecozotan in healthy young and elderly subjects. METHODS: Three randomized, double-blind, placebo-controlled, sequential, ascending dose Phase I studies of lecozotan were conducted. In a sin...

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Bibliografiske detaljer
Main Authors: Patat, Alain, Parks, Virginia, Raje, Sangeeta, Plotka, Anna, Chassard, Didier, Coz, F Le
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2009
Fag:
Pharmacokinetic Dynamic Relationships
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675040/
https://ncbi.nlm.nih.gov/pubmed/19523013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03348.x
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