A rapid, site-selective and efficient route to the dual modification of DARPins

Designed ankyrin repeat proteins (DARPins) are valuable tools in both biochemistry and medicine. Herein we describe a rapid, simple method for the dual modification of DARPins by introduction of cysteine mutations at specific positions that results in a vast difference in their thiol nucleophilicity...

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Bibliografiset tiedot
Päätekijät: Moody, Paul, Chudasama, Vijay, Nathani, Ramiz I., Maruani, Antoine, Martin, Stephen, Smith, Mark E. B., Caddick, Stephen
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Royal Society of Chemistry 2014
Aiheet:
Chemistry
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091302/
https://ncbi.nlm.nih.gov/pubmed/24687090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cc00053f
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