Cytotoxic cells kill intracellular bacteria through Granulysin-mediated delivery of Granzymes

When killer lymphocytes recognize infected cells, perforin delivers cytotoxic proteases (granzymes) into the target cell to trigger apoptosis. What happens to intracellular bacteria during this process is unclear. Human, but not rodent, cytotoxic granules also contain granulysin, an antimicrobial pe...

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Autori principali: Walch, Michael, Dotiwala, Farokh, Mulik, Sachin, Thiery, Jerome, Kirchhausen, Tomas, Clayberger, Carol, Krensky, Alan M., Martinvalet, Denis, Lieberman, Judy
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090916/
https://ncbi.nlm.nih.gov/pubmed/24906149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.03.062
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