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Two-stage designs for Phase 2 dose-finding trials
We propose a Bayesian adaptive two-stage design for the efficient estimation of the maximum dose or the minimum effective dose in a dose-finding trial. The new design allocates subjects in stage two according to the posterior distribution of the target dose location. Simulations show that the propos...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4090751/ https://ncbi.nlm.nih.gov/pubmed/22865626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.5365 |
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