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Rapid enrollment design for finding the optimal dose in immunotherapy trials with ordered groups

In immunotherapy dose-finding trials, the optimal dose is usually defined based on both toxicity and response because the relationship between toxicity and response is different than that seen with cytotoxic antineoplastic therapies. In immunotherapy trials, toxicity and response often require a lon...

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Библиографические подробности
Опубликовано в: :J Biopharm Stat
Главные авторы: Xue, Xiaoqiang, Foster, Matthew C, Ivanova, Anastasia
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791120/
https://ncbi.nlm.nih.gov/pubmed/31251112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2019.1633654
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