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Comparison of Isotonic Designs for Dose-Finding
We compare several decision rules for allocating subjects to dosages that are based on sequential isotonic estimates of a monotone dose–toxicity curve. We conclude that the decision rule in which the next assignment is to the dose having probability of toxicity closest to target does not work well....
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2821065/ https://ncbi.nlm.nih.gov/pubmed/20157632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1198/sbr.2009.0010 |
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