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An Adaptive Design for Identifying the Dose with the Best Efficacy/Tolerability Profile with Application to a Crossover Dose-Finding Study
Proof-of-concept in clinical trials has traditionally focused on identification of a maximum tolerated dose with the assumption that the higher doses provide better efficacy. However adverse events associated with a maximum tolerated dose may have a negative effect on efficacy. We present an efficie...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2772210/ https://ncbi.nlm.nih.gov/pubmed/19731265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.3684 |
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