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Adaptive dose finding based on t-statistic for dose–response trials

The goals of phase II dose–response studies are to prove that the treatment is effective and to choose the dose for further development. Randomized designs with equal allocation to either a high dose and placebo or to each of several doses and placebo are typically used. However, in trials where res...

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Detalhes bibliográficos
Main Authors: Ivanova, Anastasia, Bolognese, James A., Perevozskaya, Inna
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825484/
https://ncbi.nlm.nih.gov/pubmed/18241082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.3209
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