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Dose-Finding when the Target Dose Is on a Plateau of a Dose-Response Curve: Comparison of Fully Sequential Designs

Consider the problem of estimating a dose with a certain response rate. Many multistage dose-finding designs for this problem were originally developed for oncology studies where the mean dose-response is strictly increasing in dose. In non-oncology Phase II dose-finding studies the dose-response cu...

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Détails bibliographiques
Auteurs principaux: Ivanova, Anastasia, Xiao, Changfu
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770738/
https://ncbi.nlm.nih.gov/pubmed/23893900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pst.1585
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