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Dose-Finding when the Target Dose Is on a Plateau of a Dose-Response Curve: Comparison of Fully Sequential Designs
Consider the problem of estimating a dose with a certain response rate. Many multistage dose-finding designs for this problem were originally developed for oncology studies where the mean dose-response is strictly increasing in dose. In non-oncology Phase II dose-finding studies the dose-response cu...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3770738/ https://ncbi.nlm.nih.gov/pubmed/23893900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pst.1585 |
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