Reciprocal Regulation of Hepatic and Adipose Lipogenesis by Liver X Receptors in Obesity and Insulin Resistance

Liver X receptors (LXRs) regulate lipogenesis and inflammation, but their contribution to the metabolic syndrome is unclear. We show that LXR signaling is required for key aspects of the metabolic syndrome in obese mice. LXRαβ-deficient-ob/ob (LOKO) mice remain obese, but show reduced hepatic steato...

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Hauptverfasser: Beaven, Simon W., Matveyenko, Aleksey, Wroblewski, Kevin, Chao, Lily, Wilpitz, Damien, Hsu, Tu Wen, Lentz, Jacob, Drew, Brian, Hevener, Andrea L., Tontonoz, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4089509/
https://ncbi.nlm.nih.gov/pubmed/23823481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.04.021
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