Reciprocal Regulation of Hepatic and Adipose Lipogenesis by Liver X Receptors in Obesity and Insulin Resistance

Liver X receptors (LXRs) regulate lipogenesis and inflammation, but their contribution to the metabolic syndrome is unclear. We show that LXR signaling is required for key aspects of the metabolic syndrome in obese mice. LXRαβ-deficient-ob/ob (LOKO) mice remain obese, but show reduced hepatic steato...

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Détails bibliographiques
Auteurs principaux: Beaven, Simon W., Matveyenko, Aleksey, Wroblewski, Kevin, Chao, Lily, Wilpitz, Damien, Hsu, Tu Wen, Lentz, Jacob, Drew, Brian, Hevener, Andrea L., Tontonoz, Peter
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4089509/
https://ncbi.nlm.nih.gov/pubmed/23823481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.04.021
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