Reciprocal Regulation of Hepatic and Adipose Lipogenesis by Liver X Receptors in Obesity and Insulin Resistance

Liver X receptors (LXRs) regulate lipogenesis and inflammation, but their contribution to the metabolic syndrome is unclear. We show that LXR signaling is required for key aspects of the metabolic syndrome in obese mice. LXRαβ-deficient-ob/ob (LOKO) mice remain obese, but show reduced hepatic steato...

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Autors principals: Beaven, Simon W., Matveyenko, Aleksey, Wroblewski, Kevin, Chao, Lily, Wilpitz, Damien, Hsu, Tu Wen, Lentz, Jacob, Drew, Brian, Hevener, Andrea L., Tontonoz, Peter
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4089509/
https://ncbi.nlm.nih.gov/pubmed/23823481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.04.021
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