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Bmal1 is required for beta cell compensatory expansion, survival and metabolic adaptation to diet-induced obesity in mice

AIMS/HYPOTHESIS: Obesity and consequent insulin resistance are known risk factors for type 2 diabetes. A compensatory increase in beta cell function and mass in response to insulin resistance permits maintenance of normal glucose homeostasis, whereas failure to do so results in beta cell failure and...

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Foilsithe in:Diabetologia
Main Authors: Rakshit, Kuntol, Hsu, Tu Wen, Matveyenko, Aleksey V.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779402/
https://ncbi.nlm.nih.gov/pubmed/26762333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-015-3859-2
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