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Bmal1 is required for beta cell compensatory expansion, survival and metabolic adaptation to diet-induced obesity in mice
AIMS/HYPOTHESIS: Obesity and consequent insulin resistance are known risk factors for type 2 diabetes. A compensatory increase in beta cell function and mass in response to insulin resistance permits maintenance of normal glucose homeostasis, whereas failure to do so results in beta cell failure and...
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| Pubblicato in: | Diabetologia |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4779402/ https://ncbi.nlm.nih.gov/pubmed/26762333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-015-3859-2 |
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