Brain insulin controls adipose tissue lipolysis and lipogenesis

White adipose tissue (WAT) dysfunction plays a key role in the pathogenesis of type 2 diabetes (DM2). Unrestrained WAT lipolysis results in increased fatty acid release leading to insulin resistance and lipotoxicity, while impaired de novo lipogenesis in WAT decreases the synthesis of insulin sensit...

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Detalhes bibliográficos
Main Authors: Scherer, Thomas, O’Hare, James, Diggs-Andrews, Kelly, Schweiger, Martina, Cheng, Bob, Lindtner, Claudia, Zielinski, Elizabeth, Vempati, Prashant, Su, Kai, Dighe, Shveta, Milsom, Thomas, Puchowicz, Michelle, Scheja, Ludger, Zechner, Rudolf, Fisher, Simon J., Previs, Stephen F., Buettner, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061443/
https://ncbi.nlm.nih.gov/pubmed/21284985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.01.008
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