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Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles
The glucocorticoid receptor (GR), like many signaling proteins, depends on the Hsp90 molecular chaperone for in vivo function. Although Hsp90 is required for ligand binding in vivo, purified apoGR is capable of binding ligand with no enhancement from Hsp90. We reveal that Hsp70, known to facilitate...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4087167/ https://ncbi.nlm.nih.gov/pubmed/24949977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.04.038 |
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