Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses

JAK2 (Janus kinase 2) initiates the intracellular signalling cascade downstream of cell surface receptor activation by cognate haematopoietic cytokines, including erythropoietin and thrombopoietin. The pseudokinase (JH2) domain of JAK2 negatively regulates the catalytic activity of the adjacent tyro...

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Hlavní autoři: Varghese, Leila N., Ungureanu, Daniela, Liau, Nicholas P. D., Young, Samuel N., Laktyushin, Artem, Hammaren, Henrik, Lucet, Isabelle S., Nicola, Nicos A., Silvennoinen, Olli, Babon, Jeffrey J., Murphy, James M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4085142/
https://ncbi.nlm.nih.gov/pubmed/24354892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20131516
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